364611-21-2
364611-21-2
Chemical Structure
T2M-010
- CAS No.: 364611-21-2
- Formula:C19H17N3S
- Molecular Weight:319.42
InChIKey: LCYBPXMJDGRCBF-UHFFFAOYSA-N
SMILES: C1(CCNC2=NC(C3=CNC4=C3C=CC=C4)=CS2)=CC=CC=C1
Biological Activity: T2M-010 is a potent, brain-penetrant TREM2 agonist (Kd = 0.83 μM). T2M-010 activates receptor-proximal signaling, inducing SYK phosphorylation in TREM2-expressing cells, and promotes microglial phagocytosis. T2M-010 can be used for the study of protective microglial responses relevant to Alzheimer’s disease (AD)[1].
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T2M-010 | T2M-010 is a potent, brain-penetrant TREM2 agonist (Kd = 0.83 μM). T2M-010 activates receptor-proximal signaling, inducing SYK phosphorylation in TREM2-expressing cells, and promotes microglial phagocytosis. T2M-010 can be used for the study of protective microglial responses relevant to Alzheimer’s disease (AD). | |||||||||||||||||||||
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References
Keywords
