474328-38-6
Chemical Structure
Muraymycin D2
- CAS No.: 474328-38-6
- Formula:C37H61N11O16
- Molecular Weight:915.94
InChIKey: RRTIONDZEJYWBN-VDXVSALRSA-N
SMILES: NC[C@H]([C@H]([C@H]1O)O)O[C@H]1O[C@H]([C@@]2([H])O[C@@H](N3C(NC(C=C3)=O)=O)[C@@H]([C@@H]2O)O)[C@@H](C(O)=O)NCCCNC([C@H](CC(C)C)NC([C@H]([C@@]4([H])NC(N)=NCC4)NC(N[C@H](C(O)=O)C(C)C)=O)=O)=O
Biological Activity: Muraymycin D2 is a peptidyl nucleoside natural product derived from Streptomyces spp., possessing competitive translocase I (MraY) inhibitory activity and antibacterial activity. Muraymycin D2 competitively binds to the nucleotide-binding pocket of the MraY substrate via its nucleoside moiety, and upon binding, induces a conformational change in MraY, blocking lipid I synthesis and inhibiting peptidoglycan biosynthesis. Muraymycin D2 exhibits a Ki of 7.6 nM against Bacillus subtilis and an IC50 of 0.39 nM against Staphylococcus aureus. Muraymycin D2 shows antibacterial activity against Escherichia coli and is capable of breaking persistence in chlamydial infection. Muraymycin D2 can be used for research on bacterial infection-related studies, such as chlamydial infection[1][2][3].
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Muraymycin D2 | Muraymycin D2 is a peptidyl nucleoside natural product derived from Streptomyces spp., possessing competitive translocase I (MraY) inhibitory activity and antibacterial activity. Muraymycin D2 competitively binds to the nucleotide-binding pocket of the MraY substrate via its nucleoside moiety, and upon binding, induces a conformational change in MraY, blocking lipid I synthesis and inhibiting peptidoglycan biosynthesis. Muraymycin D2 exhibits a Ki of 7.6 nM against Bacillus subtilis and an IC50 of 0.39 nM against Staphylococcus aureus. Muraymycin D2 shows antibacterial activity against Escherichia coli and is capable of breaking persistence in chlamydial infection. Muraymycin D2 can be used for research on bacterial infection-related studies, such as chlamydial infection. | |||||||||||||||||||||
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References
- [1]. Bugg TDH, et al. Mechanism of action of nucleoside antibacterial natural product antibiotics. The Journal of antibiotics. 2019 Dec;72(12):865-876.
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[2]. Löckener I, et al. The MraY Inhibitor Muraymycin D2 and Its Derivatives Induce Enlarged Cells in Obligate Intracellular Chlamydia and Wolbachia and Break the Persistence Phenotype in Chlamydia. Antibiotics, 2024, 13: 421.
- [3]. Cui Z, et al. Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order. Antimicrobial agents and chemotherapy. 2018 Jul;62(7):e00193-18.
