504428-17-5
Chemical Structure
(1R,3S)-Compound E
- CAS No.: 504428-17-5
- Formula:C27H24F2N4O3
- Molecular Weight:490.50
IUPAC Name: (R)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
InChIKey: JNGZXGGOCLZBFB-PUAOIOHZSA-N
SMILES: FC1=CC(F)=CC(CC(N[C@H](C)C(N[C@H]2N=C(C3=CC=CC=C3)C4=CC=CC=C4N(C2=O)C)=O)=O)=C1
Biological Activity: (1R,3S)-Compound E is the isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(1R,3S)-Compound E | 99.61% | (1R,3S)-Compound E is the isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. | ||||||||||||||||||||
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Keywords
