5169-78-8
5169-78-8
Chemical Structure
Tipepidine
- CAS No.: 5169-78-8
- Formula:C15H17NS2
- Molecular Weight:275.43
IUPAC Name: 3-(di(thiophen-2-yl)methylene)-1-methylpiperidine
InChIKey: JWIXXNLOKOAAQT-UHFFFAOYSA-N
SMILES: CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3
Biological Activity: Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2].
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Tipepidine | Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect. | |||||||||||||||||||||
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References
- [1]. Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34. [Content Brief]
- [2]. Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78. [Content Brief]
Keywords
