54-80-8
54-80-8
Chemical Structure
Pronethalol
Synonym(s): (±)-Pronethalo
- CAS No.: 54-80-8
- Formula:C15H19NO
- Molecular Weight:229.32
IUPAC Name: 2-(isopropylamino)-1-(naphthalen-2-yl)ethan-1-ol
InChIKey: HRSANNODOVBCST-UHFFFAOYSA-N
SMILES: OC(CNC(C)C)C1=CC=C2C=CC=CC2=C1
Biological Activity: Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pronethalol | 99.88% | Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs). | ||||||||||||||||||||
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Pronethalol (Standard) | ≥98% | Pronethalol (Standard) is the analytical standard of Pronethalol. This product is intended for research and analytical applications. Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs). | ||||||||||||||||||||
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References
- [1]. Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-8. [Content Brief]
- [2]. Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133. [Content Brief]
Keywords
