556803-08-8
556803-08-8
Chemical Structure
TCN 213
- CAS No.: 556803-08-8
- Formula:C18H24N4OS2
- Molecular Weight:376.54
IUPAC Name: 2-((5-(benzylamino)-1,3,4-thiadiazol-2-yl)thio)-N-(cyclohexylmethyl)acetamide
InChIKey: XBAZPYFIYYCZBO-UHFFFAOYSA-N
SMILES: O=C(CSC1=NN=C(NCC2=CC=CC=C2)S1)NCC3CCCCC3
Biological Activity: TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TCN 213 | 99.16% | TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones. | ||||||||||||||||||||
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References
- [1]. McKay, S et al. “Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.” British journal of pharmacology vol. 166,3 (2012): 924-37. [Content Brief]
- [2]. Edman S, et al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep;63(3):441-9. [Content Brief]
Keywords
