56488-59-6
Chemical Structure
Terbufibrol
- CAS No.: 56488-59-6
- Formula:C20H24O5
- Molecular Weight:344.40
IUPAC Name: 4-(3-(4-(tert-butyl)phenoxy)-2-hydroxypropoxy)benzoic acid
InChIKey: PXODZCMXOZRVEN-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(OCC(O)COC2=CC=C(C(C)(C)C)C=C2)C=C1
Biological Activity: Terbufibrol is an orally active lipid-lowering agent. Terbufibrol inhibits hepatic Cholesterol 7 alpha-hydroxylase. Terbufibrol blocks a step between Acetate and HMG-CoA in the hepatic cholesterol synthesis process. Terbufibrol reduces serum total cholesterol, HDL, LDL, lipoprotein levels, and the cholesterol/phospholipid ratio, with dose- and sex-dependent changes in lipoprotein components. Terbufibrol exerts sustained cholesterol-lowering activity in baboons and rats. Terbufibrol can be used in research related to hypercholesterolemia[1][2].
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Terbufibrol | 98.39% | Terbufibrol is an orally active lipid-lowering agent. Terbufibrol inhibits hepatic Cholesterol 7 alpha-hydroxylase. Terbufibrol blocks a step between Acetate and HMG-CoA in the hepatic cholesterol synthesis process. Terbufibrol reduces serum total cholesterol, HDL, LDL, lipoprotein levels, and the cholesterol/phospholipid ratio, with dose- and sex-dependent changes in lipoprotein components. Terbufibrol exerts sustained cholesterol-lowering activity in baboons and rats. Terbufibrol can be used in research related to hypercholesterolemia. | ||||||||||||||||||||
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Terbufibrol (Standard) | ≥98% | Terbufibrol (Standard) is the analytical standard of Terbufibrol (HY-101812). This product is intended for research and analytical applications. Terbufibrol has been shown highly active in reducing serum total cholesterol (TC) levels in the normal and hypercholesterolemic male rat. | ||||||||||||||||||||
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- [1]. Howard AN, et al. The hypocholesterolemic effect of terbufibrol and other drugs in normal and hypercholesterolemic baboons. Atherosclerosis. 1979 Apr;32(4):367-80. [Content Brief]
- [2]. Löser R, et al. Mode of action of terbufibrol (INN) a hypolipidemic agent on rat liver sterol synthesis. Artery. 1982;10(3):180-92. [Content Brief]
Keywords
