639087-64-2

CP-654577 Chemical Structure
639087-64-2

Chemical Structure

CP-654577

  • CAS No.: 639087-64-2
  • Formula:C34H32N4O3
  • Molecular Weight:544.66

IUPAC Name: ((1R,5S,6r)-3-(4-(4-((3-methoxy-4-phenoxyphenyl)amino)quinazolin-6-yl)benzyl)-3-azabicyclo[3.1.0]hexan-6-yl)methanol

InChIKey: WZZXMNBOPNKKSX-BKHFGAQXSA-N

SMILES: C(O)[C@H]1[C@]2([C@@]1(CN(CC3=CC=C(C=C3)C4=CC=5C(NC6=CC(OC)=C(OC7=CC=CC=C7)C=C6)=NC=NC5C=C4)C2)[H])[H]

Biological Activity: CP-654577 is a selective ErbB2 inhibitor with an IC50 of 11 nM. CP-654577 downregulates the Notch1 signaling pathway. CP-654577 upregulates p27kip1, reduces the levels of Cyclins D and E, and inhibits G1 phase progression of the cell cycle. CP-654577 induces cell Apoptosis, downregulates activated Akt, and suppresses tumor growth in athymic mice. CP-654577 can be used in breast cancer-related research[1][2][3].

Cat. No. Nom du produit Pureté Description Pricing
HY-118900 		CP-654577 CP-654577 is a selective ErbB2 inhibitor with an IC50 of 11 nM. CP-654577 downregulates the Notch1 signaling pathway. CP-654577 upregulates p27kip1, reduces the levels of Cyclins D and E, and inhibits G1 phase progression of the cell cycle. CP-654577 induces cell Apoptosis, downregulates activated Akt, and suppresses tumor growth in athymic mice. CP-654577 can be used in breast cancer-related research.
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