639089-73-9
639089-73-9
Chemical Structure
VE-465
- CAS No.: 639089-73-9
- Formula:C22H28N8OS
- Molecular Weight:452.58
IUPAC Name: N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)thio)phenyl)propionamide
InChIKey: LCQYMDMUCJFFKN-UHFFFAOYSA-N
SMILES: CCC(NC1=CC=C(C=C1)SC2=NC(NC3=NNC(C)=C3)=CC(N4CCN(CC4)C)=N2)=O
Biological Activity: VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].
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VE-465 | VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models. | |||||||||||||||||||||
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References
- [1]. Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50(3):518-27. [Content Brief]
- [2]. Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49(3):559-69. [Content Brief]
Keywords
