679789-44-7
Chemical Structure
Mono(2-ethyl-5-oxohexyl) phthalate-d4
Synonym(s): MEOHP-d4; 5-oxo-MEHP-d4
- CAS No.: 679789-44-7
- Formula:C16H16D4O5
- Molecular Weight:296.35
IUPAC Name: 2-hydroxy-3-phenylpropanoic-2,3,3-d3 acid
InChIKey: HCWNFKHKKHNSSL-UGWFXTGHSA-N
SMILES: CC(CCC(CC)COC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])C(O)=O)=O)=O
Biological Activity: Mono(2-ethyl-5-oxohexyl) phthalate-d4 (MEOHP-d4; 5-oxo-MEHP-d4) is the deuterated-labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono (2-ethyl-5-oxohexyl) phthalate (MEOHP; 5-oxo-MEHP) is a secondary metabolite produced by cytochrome P450 enzyme-mediated oxidation of di(2-ethylhexyl) phthalate. Exposure levels of Mono (2-ethyl-5-oxohexyl) phthalate are associated with late-onset hypogonadism. Mono (2-ethyl-5-oxohexyl) phthalate can be used for research on mechanisms related to male reproductive endocrine disorders[1][2][3].
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Mono(2-ethyl-5-oxohexyl) phthalate-d4 | Mono(2-ethyl-5-oxohexyl) phthalate-d4 (MEOHP-d4; 5-oxo-MEHP-d4) is the deuterated-labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono (2-ethyl-5-oxohexyl) phthalate (MEOHP; 5-oxo-MEHP) is a secondary metabolite produced by cytochrome P450 enzyme-mediated oxidation of di(2-ethylhexyl) phthalate. Exposure levels of Mono (2-ethyl-5-oxohexyl) phthalate are associated with late-onset hypogonadism. Mono (2-ethyl-5-oxohexyl) phthalate can be used for research on mechanisms related to male reproductive endocrine disorders. | |||||||||||||||||||||
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Mono(2-ethyl-5-oxohexyl) phthalate | 99.59% | Mono (2-ethyl-5-oxohexyl) phthalate (MEOHP; 5-oxo-MEHP) is a secondary metabolite produced by cytochrome P450 enzyme-mediated oxidation of di(2-ethylhexyl) phthalate. Exposure levels of Mono (2-ethyl-5-oxohexyl) phthalate are associated with late-onset hypogonadism. Mono (2-ethyl-5-oxohexyl) phthalate can be used for research on mechanisms related to male reproductive endocrine disorders. | ||||||||||||||||||||
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References
- [1]. Beg MA, et al. Endocrine Disruption: Structural Interactions of Androgen Receptor against Di(2-ethylhexyl) Phthalate and Its Metabolites. Toxics. 2020 Dec 08;8(4):115.
- [2]. Choi K, et al. In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat. Toxicology in vitro : an international journal published in association with BIBRA. 2012 Mar;26(2):315-22.
- [3]. Liu ZH, et al. The relationship between exposure to phthalate metabolites and adult-onset hypogonadism. Frontiers in endocrinology. 2022;13:991497.
