688310-17-0
688310-17-0
Chemical Structure
H36-E4
- CAS No.: 688310-17-0
- Formula:C10H15N5O3
- Molecular Weight:253.26
InChIKey: LMOYCQUJCWSVCN-UHFFFAOYSA-N
SMILES: NC(C1CCN(CC1)C2=C(N=CN2C)[N+]([O-])=O)=O
Biological Activity: H36-E4 is a WW domain containing E3 ubiquitin 27 protein ligase 2 (WWP2) inhibitor with a KD of 6.25 μM. H36-E4 inhibits WWP2 expression, restores the succinate dehydrogenase complex subunit C (SDHC) level, and defers the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition in unilateral kidney ischemia-reperfusion (UIR) mice. H36-E4 can be used for AKI-to-CKD transition research[1].
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H36-E4 | 98.57% | H36-E4 is a WW domain containing E3 ubiquitin 27 protein ligase 2 (WWP2) inhibitor with a KD of 6.25 μM. H36-E4 inhibits WWP2 expression, restores the succinate dehydrogenase complex subunit C (SDHC) level, and defers the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition in unilateral kidney ischemia-reperfusion (UIR) mice. H36-E4 can be used for AKI-to-CKD transition research. | ||||||||||||||||||||
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References
Keywords
