71369-60-3
71369-60-3
Chemical Structure
(+)-Talinolol
Synonym(s): (+)-Cordanum
- CAS. Nr.: 71369-60-3
- Formula:C20H33N3O3
- Molecular Weight:363.49
InChIKey: MXFWWQICDIZSOA-QGZVFWFLSA-N
SMILES: CC(C)(NC[C@H](COC1=CC=C(NC(NC2CCCCC2)=O)C=C1)O)C
Biological Activity: (+)-Talinolol is an isomer of Talinolol (HY-108286). Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity[1][2].
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(+)-Talinolol | (+)-Talinolol is an isomer of Talinolol (HY-108286). Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity. | |||||||||||||||||||||
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References
- [1]. Assmann I. The actions of talinolol, a beta 1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction. Curr Med Res Opin. 1995;13(6):325-42. [Content Brief]
- [2]. Kara ZP, et, al. The effects of P-glycoprotein inhibitor zosuquidar on the sex and time-dependent pharmacokinetics of parenterally administered talinolol in mice. Eur J Pharm Sci. 2021 Jan 1;156:105589. [Content Brief]
