716354-04-0
Chemical Structure
GSK163929
- CAS No.: 716354-04-0
- Formula:C36H40ClF2N5O3S
- Molecular Weight:696.25
IUPAC Name: 4-chloro-2-fluoro-5-(4-(3-fluorophenyl)-4-(2-((1R,5S)-3-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl)ethyl)piperidine-1-carbonyl)-N-methylbenzenesulfonamide
InChIKey: AWXQYTLSBPWDMJ-FITHBNAOSA-N
SMILES: CC1=NC2=C(C=CC=C2)N1C3C[C@H](CC4)N([C@H]4C3)CCC5(C6=CC(F)=CC=C6)CCN(C(C7=CC(S(=O)(NC)=O)=C(F)C=C7Cl)=O)CC5
Biological Activity: GSK163929 (compound 122) is an orally active, anti-HIV CCR5 antagonist with low inhibitory potency against hEGR. GSK163929 had no adverse effects in rats at 2000 mg/kg/day (i.v., 7 d) and in dogs at 250 mg/kg/day (i.v., 7 d)[1].
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GSK163929 | GSK163929 (compound 122) is an orally active, anti-HIV CCR5 antagonist with low inhibitory potency against hEGR. GSK163929 had no adverse effects in rats at 2000 mg/kg/day (i.v., 7 d) and in dogs at 250 mg/kg/day (i.v., 7 d). | |||||||||||||||||||||
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Keywords
