71965-46-3
Chemical Structure
Cathepsin S, human
Synonym(s): CTSS
- CAS No.: 71965-46-3
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Cathepsin S, human]
Biological Activity: Human Cathepsin S (CTSS) is a cysteine protease with elastinolytic activity. Human Cathepsin S is inhibited by cysteine protease inhibitors such as E-64 (HY-15282) and cystatin C. Human Cathepsin S cleaves substrates including elastin, TGF-β1, Myelin basic protein (HY-P1821), PAR2, SIRT1, collagen 18A1, FKN, and MHC-II invariant chain fragments, thereby driving processes such as elastic matrix degradation, TGF-β1 signaling, demyelination, PAR2-mediated calcium mobilization, NF-κB activation, hepatic fibrosis, immune homeostasis regulation, and antigen presentation. Human Cathepsin S can be used in the research of cardiovascular diseases, chronic kidney diseases, autoimmune diseases, tumors, Alzheimer's disease, and obesity[1][2][3][4][5].
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Cathepsin S, human | Human Cathepsin S (CTSS) is a cysteine protease with elastinolytic activity. Human Cathepsin S is inhibited by cysteine protease inhibitors such as E-64 (HY-15282) and cystatin C. Human Cathepsin S cleaves substrates including elastin, TGF-β1, Myelin basic protein (HY-P1821), PAR2, SIRT1, collagen 18A1, FKN, and MHC-II invariant chain fragments, thereby driving processes such as elastic matrix degradation, TGF-β1 signaling, demyelination, PAR2-mediated calcium mobilization, NF-κB activation, hepatic fibrosis, immune homeostasis regulation, and antigen presentation. Human Cathepsin S can be used in the research of cardiovascular diseases, chronic kidney diseases, autoimmune diseases, tumors, Alzheimer's disease, and obesity. | |||||||||||||||||||||
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- [1]. Gao H, et al. Cathepsin S: molecular mechanisms in inflammatory and immunological processes. Frontiers in immunology. 2025;16:1600206.
- [2]. Smyth P, et al. Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential. Molecular aspects of medicine. 2022 Dec;88:101106.
- [3]. Wilkinson RD, et al. Cathepsin S: therapeutic, diagnostic, and prognostic potential. Biological chemistry. 2015 Aug;396(8):867-82. [Content Brief]
- [4]. Shi GP, et al. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. The Journal of biological chemistry. 1992 Apr 15;267(11):7258-62.
- [5]. Bania J, et al. Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs. Proceedings of the National Academy of Sciences of the United States of America. 2003 May 27;100(11):6664-9.
Keywords
