79786-08-6
Chemical Structure
Tellimagrandin I
- CAS No.: 79786-08-6
- Formula:C34H26O22
- Molecular Weight:786.56
IUPAC Name: (11aR,13R,14R,15S,15aR)-2,3,4,5,6,7,13-heptahydroxy-9,17-dioxo-9,11,11a,13,14,15,15a,17-octahydrodibenzo[g,i]pyrano[3,2-b][1,5]dioxacycloundecine-14,15-diyl bis(3,4,5-trihydroxybenzoate)
InChIKey: YKDNTEQLKGYZHT-JSAIFSMWSA-N
SMILES: O=C(OC[C@H]1O[C@@H](O)[C@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)[C@@H](OC(C3=CC(O)=C(O)C(O)=C3)=O)[C@@H]1OC(C4=CC(O)=C(O)C(O)=C45)=O)C6=C5C(O)=C(O)C(O)=C6
Biological Activity: Tellimagrandin I is a gap junction protein 43 (Cx43) activator, which is a hydrolyzable ellagitannin (ellagitannin) secondary metabolite extractable from various plants. Tellimagrandin I mainly restores gap junction intercellular communication (GJIC) and induces S-phase arrest in tumor cells by upregulating Cx43; activates inflammatory cells to release TNF-α and VEGF to promote angiogenesis in vivo; and protects DNA from damage via antioxidant and metal chelating effects. Tellimagrandin I can be used in research related to human cervical cancer[1][2][3][4].
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Tellimagrandin I | Tellimagrandin I is a gap junction protein 43 (Cx43) activator, which is a hydrolyzable ellagitannin (ellagitannin) secondary metabolite extractable from various plants. Tellimagrandin I mainly restores gap junction intercellular communication (GJIC) and induces S-phase arrest in tumor cells by upregulating Cx43; activates inflammatory cells to release TNF-α and VEGF to promote angiogenesis in vivo; and protects DNA from damage via antioxidant and metal chelating effects. Tellimagrandin I can be used in research related to human cervical cancer. | |||||||||||||||||||||
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References
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[1]. Ken S. Feldman, et
al. Ellagitannin Chemistry. The First Total Chemical Synthesis of an Ellagitannin Natural Product, Tellimagrandin I. Journal American Chemical Society 1 March 1994; 116 (5): 1742–1745. - [2]. Fernandes AS, et al. Pedunculagin and tellimagrandin-I stimulate inflammation and angiogenesis and upregulate vascular endothelial growth factor and tumor necrosis factor-alpha in vivo. Microvascular research. 2024 Jan;151:104615. [Content Brief]
- [3]. Yi ZC, et al. Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro. Cancer letters. 2006 Oct 08;242(1):77-87. [Content Brief]
- [4]. Fernandes AS, et al. Tellimagrandin-I and camptothin a exhibit chemopreventive effects in Salmonella enterica serovar Typhimurium strains and human lymphocytes. J Toxicol Environ Health A. 2024 Mar 3;87(5):185-198. [Content Brief]
