825649-28-3
Chemical Structure
JNJ-20788560
- CAS No.: 825649-28-3
- Formula:C25H28N2O2
- Molecular Weight:388.50
IUPAC Name: 9-(8-azabicyclo[3.2.1]octan-3-ylidene)-N,N-diethyl-9H-xanthene-3-carboxamide
InChIKey: MISSUZBVOCUXTG-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2/C(C3=CC=CC=C3OC2=C1)=C4CC(CC5)NC5C/4)N(CC)CC
Biological Activity: JNJ-20788560 is a selective and orally active delta opioid receptor agonist with an affinity of 2.0 nM for DOR (rat brain cortex binding assay). JNJ-20788560 also is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence. JNJ-20788560 can be used for the research of the relief of inflammatory hyperalgesia[1].
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JNJ-20788560 | 98.05% | JNJ-20788560 is a selective and orally active delta opioid receptor agonist with an affinity of 2.0 nM for DOR (rat brain cortex binding assay). JNJ-20788560 also is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence. JNJ-20788560 can be used for the research of the relief of inflammatory hyperalgesia. | ||||||||||||||||||||
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- [1]. Codd EE, et al. JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence. J Pharmacol Exp Ther. 2009 Apr;329(1):241-51. [Content Brief]
Keywords
