844442-32-6
844442-32-6
Chemical Structure
SGC-CDKL5/GSK3
- CAS No.: 844442-32-6
- Formula:C16H17F2N5O2
- Molecular Weight:349.34
InChIKey: NIHAFOURWLZLFN-UHFFFAOYSA-N
SMILES: O=C(C1=CC(F)=CC(F)=C1)NC2=CNN=C2C(NC3CCNCC3)=O
Biological Activity: CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3α/β, with IC50 values of 4.6, 24 and 9.5 nM for CDKL5, GSK3β and GSK3α, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SGC-CDKL5/GSK3 | 98.72% | CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3α/β, with IC50 values of 4.6, 24 and 9.5 nM for CDKL5, GSK3β and GSK3α, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases. | ||||||||||||||||||||
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References
Keywords
