850550-70-8
850550-70-8
Chemical Structure
CD28-IN-3
- CAS No.: 850550-70-8
- Formula:C17H24N4OS2
- Molecular Weight:364.53
InChIKey: HNRNZFFGRFUPRF-UHFFFAOYSA-N
SMILES: CCC(NC(CSC1=NN=C(S1)NC2=CC=C(C=C2)C(C)C)=O)C
Biological Activity: CD28-IN-3 is a CD28 inhibitor with an IC50 of 7.80 μM and a Kd of 52.45 μM. CD28-IN-3 selectively blocks the CD28-B7 interaction, thereby inhibiting CD28-mediated costimulation. CD28-IN-3 suppresses the production of proinflammatory cytokines IFN-γ, IL-2 and TNF-α. CD28-IN-3 can be used in the research of checkpoint-resistant cancers[1].
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CD28-IN-3 | CD28-IN-3 is a CD28 inhibitor with an IC50 of 7.80 μM and a Kd of 52.45 μM. CD28-IN-3 selectively blocks the CD28-B7 interaction, thereby inhibiting CD28-mediated costimulation. CD28-IN-3 suppresses the production of proinflammatory cytokines IFN-γ, IL-2 and TNF-α. CD28-IN-3 can be used in the research of checkpoint-resistant cancers. | |||||||||||||||||||||
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References
Keywords
