865111-04-2
Chemical Structure
MK-0668 mesylate
- CAS No.: 865111-04-2
- Formula:C32H34Cl2N6O9S2
- Molecular Weight:781.68
IUPAC Name: (S)-2-((2S,4R)-1-((3-cyanophenyl)sulfonyl)-4-(cyclobutylamino)pyrrolidine-2-carboxamido)-3-(4-(3,5-dichloroisonicotinamido)phenyl)propanoic acid compound with methanesulfonic acid (1:1)
InChIKey: KHZPBUGRFNTMOR-YHEIIOCHSA-N
SMILES: O=C([C@@H](NC([C@H]1N(C[C@@H](C1)NC2CCC2)S(=O)(C3=CC=CC(C#N)=C3)=O)=O)CC4=CC=C(C=C4)NC(C5=C(C=NC=C5Cl)Cl)=O)O.CS(=O)(O)=O
Biological Activity: MK-0668 mesylate is an amino acid-based, potent antagonist of unactivated VLA-4, with an IC50) of 0.13 nM in human whole blood. And MK-0668 mesylate exhibits IC50s of 0.19 nM in dogs, 0.21 nM in rhesus monkeys, and 0.4 nM in rats[1].
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MK-0668 mesylate | MK-0668 mesylate is an amino acid-based, potent antagonist of unactivated VLA-4, with an IC50) of 0.13 nM in human whole blood. And MK-0668 mesylate exhibits IC50s of 0.19 nM in dogs, 0.21 nM in rhesus monkeys, and 0.4 nM in rats. | |||||||||||||||||||||
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Keywords
