86811-36-1
Chemical Structure
PT-262
- CAS. Nr.: 86811-36-1
- Formula:C14H13ClN2O2
- Molecular Weight:276.72
IUPAC Name: 7-chloro-6-(piperidin-1-yl)quinoline-5,8-dione
InChIKey: XBHXHCMFAUSIKK-UHFFFAOYSA-N
SMILES: O=C(C(N1CCCCC1)=C2Cl)C3=C(N=CC=C3)C2=O
Biological Activity: PT-262 is a potent ROCK inhibitor with an IC50 value of around 5 μM. PT-262 induces the loss of mitochondrial membrane potential and elevates the caspase-3 activation and apoptosis. PT-262 inhibits the ERK and CDC2 phosphorylation via a p53-independent pathway. PT-262 blocks cytoskeleton function and cell migration. PT-262 has anti-cancer activity[1][2].
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PT-262 | 99.21% | PT-262 is a potent ROCK inhibitor with an IC50 value of around 5 μM. PT-262 induces the loss of mitochondrial membrane potential and elevates the caspase-3 activation and apoptosis. PT-262 inhibits the ERK and CDC2 phosphorylation via a p53-independent pathway. PT-262 blocks cytoskeleton function and cell migration. PT-262 has anti-cancer activity. | ||||||||||||||||||||
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- [1]. Tzu-Sheng Hsu, et al. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway. Cancer Chemother Pharmacol. 2008 Oct;62(5):799-808. [Content Brief]
- [2]. Chih-Chien Tsai, et al. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration. Biochem Pharmacol. 2011 Apr 1;81(7):856-65. [Content Brief]
Keywords
