87495-33-8
87495-33-8
Chemical Structure
Napamezole hydrochloride
- CAS No.: 87495-33-8
- Formula:C14H17ClN2
- Molecular Weight:248.75
IUPAC Name: 2-((3,4-dihydronaphthalen-2-yl)methyl)-4,5-dihydro-1H-imidazole hydrochloride
InChIKey: QSIVIHAAKDQDHY-UHFFFAOYSA-N
SMILES: C1(CC2=CC3=C(CC2)C=CC=C3)=NCCN1.Cl
Biological Activity: Napamezole hydrochloride is an orally active α-2 adrenergic receptor antagonist and serotonin (5-HT Receptor) reuptake inhibitor, with Ki values of 28 nM and 93 nM for rat α-2 and α-1 adrenergic receptors, respectively. Napamezole hydrochloride can be used for the research of depression[1][2].
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Napamezole hydrochloride | 98.97% | Napamezole hydrochloride is an orally active α-2 adrenergic receptor antagonist and serotonin (5-HT Receptor) reuptake inhibitor, with Ki values of 28 nM and 93 nM for rat α-2 and α-1 adrenergic receptors, respectively. Napamezole hydrochloride can be used for the research of depression. | ||||||||||||||||||||
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References
- [1]. Perrone MH, et al. In vivo assessment of napamezole, an alpha-2 adrenoceptor antagonist and monoamine re-uptake inhibitor. J Pharmacol Exp Ther. 1990;254(2):476-483. [Content Brief]
- [2]. Perrone MH, et al. Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro. J Pharmacol Exp Ther. 1990;254(2):471-475. [Content Brief]
Keywords
