89520-11-6
89520-11-6
Chemical Structure
N-Bromoacetyl-β-alanine
- CAS No.: 89520-11-6
- Formula:C5H8BrNO3
- Molecular Weight:210.03
IUPAC Name: 3-(2-bromoacetamido)propanoic acid
InChIKey: ULKDIPSSLZFIQU-UHFFFAOYSA-N
SMILES: O=C(O)CCNC(CBr)=O
Biological Activity: N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
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N-Bromoacetyl-β-alanine | N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | |||||||||||||||||||||
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References
- [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
- [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]
Keywords
