908027-21-4
Chemical Structure
MI 63
- CAS No.: 908027-21-4
- Formula:C29H35Cl2FN4O3
- Molecular Weight:577.52
IUPAC Name: (2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(2-morpholinoethyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide
InChIKey: YTBYOWZWBDYLQF-BGLPIVGWSA-N
SMILES: O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5
Biological Activity: MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS[1].
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MI 63 | MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS. | |||||||||||||||||||||
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Keywords
