90961-53-8
Chemical Structure
Tedisamil
Synonym(s): KC-8857
- CAS No.: 90961-53-8
- Formula:C19H32N2
- Molecular Weight:288.47
IUPAC Name: (1s,5s)-3,7-bis(cyclopropylmethyl)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane]
InChIKey: CTIRHWCPXYGDGF-HDICACEKSA-N
SMILES: [C@@H](CN1CC2CC2)(C3)C4(CCCC4)[C@@H](C1)CN3CC5CC5
Biological Activity: Tedisamil (KC-8857) is an antiarrhythmic compound with important biological activities. Tedisamil exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models[1].
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Tedisamil | Tedisamil (KC-8857) is an antiarrhythmic compound with important biological activities. Tedisamil exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models. | |||||||||||||||||||||
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Keywords
