916489-36-6
916489-36-6
Chemical Structure
MS417
Synonym(s): GTPL7512
- CAS No.: 916489-36-6
- Formula:C20H19ClN4O2S
- Molecular Weight:414.91
IUPAC Name: methyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
InChIKey: GGRCIHACOIMRKY-HNNXBMFYSA-N
SMILES: O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
Biological Activity: MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MS417 | 99.79% | MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
MS417 (Standard) | ≥98% | MS417 (Standard) is the analytical standard of MS417 (HY-111139). This product is intended for research and analytical applications. MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.91
HY-78695JQ-1 carboxylic acid -
Similarity Score 0.91
HY-78695A(R)-JQ-1 carboxylic acid -
Similarity Score 0.90
HY-13030(+)-JQ-1 -
Similarity Score 0.90
HY-13030A(R)-(-)-JQ1 Enantiomer -
Similarity Score 0.90
HY-137075(±)-JQ1 -
Similarity Score 0.89
HY-15846CPI-203 -
Similarity Score 0.89
HY-15846A(Rac)-CPI-203 -
Similarity Score 0.88
HY-176438DDL-357 -
Similarity Score 0.87
HY-116349Bromodomain IN-1 -
Explore the MedChemAI to find more analogs
