92615-20-8
92615-20-8
Chemical Structure
Nafenodone
- CAS No.: 92615-20-8
- Formula:C20H23NO
- Molecular Weight:293.40
InChIKey: IOKKIRANVRFSAH-UHFFFAOYSA-N
SMILES: O=C1C2=C(CCC1(CCN(C)C)C3=CC=CC=C3)C=CC=C2
Biological Activity: Nafenodone is an antidepressant agent. Nafenodone can reduce the rate and amplitude of contractions and lengthen sinus node recovery time. Nafenodone can inhibit the spontaneous mechanical activity in portal vein segmens with an IC50 of 1.4 μM in rat isolated vascular smooth muscle. Nafenodone relaxes the contractions induced by high K+ and noradrenaline[1][2].
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Nafenodone | Nafenodone is an antidepressant agent. Nafenodone can reduce the rate and amplitude of contractions and lengthen sinus node recovery time. Nafenodone can inhibit the spontaneous mechanical activity in portal vein segmens with an IC50 of 1.4 μM in rat isolated vascular smooth muscle. Nafenodone relaxes the contractions induced by high K+ and noradrenaline. | |||||||||||||||||||||
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References
- [1]. Pérez-Vizcaino, F., et al., (1991). Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres. European journal of pharmacology, 199(1), 43-50. [Content Brief]
- [2]. Pérez-Vizcaíno, F., et al., (1993). Effects of (S)-nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle. European journal of pharmacology, 232(1), 105-111. [Content Brief]
Keywords
