927691-21-2
Chemical Structure
PQ-10
- CAS No.: 927691-21-2
- Formula:C22H21N5O3
- Molecular Weight:403.43
IUPAC Name: (R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
InChIKey: UBIIFKJMNRPNMT-CQSZACIVSA-N
SMILES: COC1=CC(C(N(CC2)C[C@@H]2OC3=NC(C=CC=C4)=C4N=C3)=NC=N5)=C5C=C1OC
Biological Activity: PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia[1].
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PQ-10 | 99.41% | PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia. | ||||||||||||||||||||
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Keywords
