936487-67-1
Chemical Structure
SF1126
- No. CAS: 936487-67-1
- Formula:C39H48N8O14
- Molecular Weight:852.84
IUPAC Name: (8S,14S)-14-(((S)-1-carboxy-2-hydroxyethyl)carbamoyl)-8-(3-guanidinopropyl)-3,6,9,12-tetraoxo-1-(4-(4-oxo-8-phenyl-4H-chromen-2-yl)morpholino-4-ium)-2-oxa-7,10,13-triazahexadecan-16-oate
InChIKey: SVNJBEMPMKWDCO-KCHLEUMXSA-N
SMILES: N=C(N)NCCC[C@H](NC(CCC(OC[N+]1(CCOCC1)C(OC(C2=CC=C3)=C3C4=CC=CC=C4)=CC2=O)=O)=O)C(NCC(N[C@@H](CC([O-])=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O
Biological Activity: SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor, has antitumor and anti-angiogenic activity. SF1126 is an RGDS-conjugated LY294002 proagent, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment. SF1126 induces cell apoptosis[1].
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SF1126 | SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor, has antitumor and anti-angiogenic activity. SF1126 is an RGDS-conjugated LY294002 proagent, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment. SF1126 induces cell apoptosis. | |||||||||||||||||||||
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Keywords
