957762-36-6
957762-36-6
Chemical Structure
MJE3
- CAS No.: 957762-36-6
- Formula:C35H40N2O7
- Molecular Weight:600.71
IUPAC Name: 2-((3S,4S,6S)-4-((((S)-1-(benzyloxy)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)oxy)-1-oxaspiro[2.5]octan-6-yl)propan-2-yl hex-5-ynoate
InChIKey: OUZLIMFGHKWCDE-ODSVIUALSA-N
SMILES: O(C(N[C@@H](CC=1C=2C(NC1)=CC=CC2)C(OCC3=CC=CC=C3)=O)=O)[C@@H]4[C@@]5(CO5)CC[C@H]([C@](OC(CCCC#C)=O)(C)C)C4
Biological Activity: MJE3 is a cell-permeable small-molecule phosphoglycerate mutase 1 (PGAM1) inhibitor. MJE3 is applicable to research related to breast cancer and melanoma[1][2][3][4].
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MJE3 | MJE3 is a cell-permeable small-molecule phosphoglycerate mutase 1 (PGAM1) inhibitor. MJE3 is applicable to research related to breast cancer and melanoma. | |||||||||||||||||||||
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References
- [1]. Evans MJ, et al. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nature biotechnology. 2005 Oct;23(10):1303-7.
- [2]. Evans MJ, et al. Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides. Molecular bioSystems. 2007 Jul;3(7):495-506.
- [3]. Elf SE, et al. Targeting glucose metabolism in patients with cancer. Cancer. 2014 Mar 15;120(6):774-80.
- [4]. Jiang X, et al. The role of phosphoglycerate mutase 1 in tumor aerobic glycolysis and its potential therapeutic implications. International journal of cancer. 2014 Nov 01;135(9):1991-6.
Keywords
