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Art. -Nr.: HY-149641

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CDK9-IN-29

CDK9-IN-29 (compound Z11) is a potent CDK9 inhibitor (IC₅₀ = 3.20 nM) with good kinase selectivity. CDK9-IN-29 inhibits cell proliferation and induces apoptosis.

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CAS. Nr.: 2737262-24-5
Formel: C₂₉H₃₃F₂N₅O₄
Molecular Weight:553.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CDK9-IN-29 Chemical Structure

CAS. Nr.: 2737262-24-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CDK9-IN-29 (compound Z11) is a potent CDK9 inhibitor (IC₅₀ = 3.20 nM) with good kinase selectivity. CDK9-IN-29 inhibits cell proliferation and induces apoptosis^[1].

Alle CDK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.409 μM Compound: Z11	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
HCC827	IC₅₀	0.315 μM Compound: Z11	Antiproliferative activity against human HCC827 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCC827 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1299	IC₅₀	0.085 μM Compound: Z11	Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	<0.05 μM Compound: Z11	Antiproliferative activity against 3D-cultured human Osimertinib-resistant NCI-H1975 cell incubated for 72 hrs by MTT assay Antiproliferative activity against 3D-cultured human Osimertinib-resistant NCI-H1975 cell incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	0.083 μM Compound: Z11	Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell assessed as cell growth inhibition incubated for 72 hrs in presence of osimertinib by MTT assay Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell assessed as cell growth inhibition incubated for 72 hrs in presence of osimertinib by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	0.174 μM Compound: Z11	Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	0.19 μM Compound: Z11	Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	0.251 μM Compound: Z11	Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell incubated for 72 hrs by MTT assay Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H596	IC₅₀	0.332 μM Compound: Z11	Antiproliferative activity against human NCI-H596 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H596 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
PC-9	IC₅₀	0.126 μM Compound: Z11	Antiproliferative activity against human PC-9 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human PC-9 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]

Chemical Information

CAS. Nr. 2737262-24-5
Molecular Weight 553.60
Formel C₂₉H₃₃F₂N₅O₄
SMILES

FC1=C(C=C(C=C1)C2=C(C=NC(N3)=N2)F)OCCCCCCOC4=CC3=CC=C4C(NCCN5CCOCC5)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tizhi Wu, et al. Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2023. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CDK9-IN-29

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CDK9-IN-29 Related Classifications

HY-149641 Related Classifications