Lrrk2 - leucine-rich repeat kinase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300160

About Lrrk2

Primary_assembly 7: 122,826,696-122,987,703 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 52 phenotypes. Biased expression in Lung (RPKM 24.9), Spleen (RPKM 172.7) and 8 other tissues.

Summary

Predicted to enable several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of macromolecule metabolic process; and positive regulation of microglial cell activation. Located in several cellular components, including axon; dendrite; and perikaryon. Used to study neurodegenerative disease. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk2 Products (1)

mRNA Protein Name
NM_001191789.2 NP_001178718.2 leucine-rich repeat serine/threonine-protein kinase 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19879924 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17114044 RGD
involved in neuron projection arborization IMP
IMP: Inferred from mutant phenotype
17114044 RGD
involved in positive regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
22302802 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
22302802 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
18445495 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22302802 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
20403420 RGD
involved in striatum development IEP
IEP: Inferred from expression pattern
18272292 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in axon IDA
IDA: Inferred from direct assay
17114044 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17114044 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18445495 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17114044 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
18445495 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lrrk2 Protein Structure

LRR_RI

LRR_RI: sd00033 (983 - 1010)

PRK15370

PRK15370: cl33128 (1009 - 1257)

LRR_RI

LRR_RI: sd00033 (1011 - 1034)

LRR_RI

LRR_RI: sd00033 (1035 - 1057)

LRR_RI

LRR_RI: sd00033 (1058 - 1082)

LRR_RI

LRR_RI: sd00033 (1083 - 1106)

LRR_RI

LRR_RI: sd00033 (1107 - 1128)

LRR_RI

LRR_RI: sd00033 (1129 - 1172)

LRR_RI

LRR_RI: sd00033 (1173 - 1195)

LRR_RI

LRR_RI: sd00033 (1196 - 1219)

LRR_RI

LRR_RI: sd00033 (1220 - 1244)

RocCOR

RocCOR: cd09914 (1332 - 1505)

COR

COR: cl24610 (1525 - 1738)

STKc_LRRK2

STKc_LRRK2: cd14068 (1882 - 2133)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2526 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat serine/threonine-protein kinase 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-112809 GSK2646264 Inhibitor 99.74% Phase 1

Pre-clinical Phase

Bioactive Molecules (63)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-100411 MLi-2 Inhibitor 99.80% Unkown
HY-13687 IKK 16 Inhibitor 99.88% Unkown
HY-10875 LRRK2-IN-1 Inhibitor 99.04% Unkown
HY-148030 XL01126 Inhibitor 98.90% Unkown
HY-40294 Indazole Inhibitor 99.83% Unkown
HY-12477 PF-06447475 Inhibitor 99.94% Unkown
HY-15796 GNE0877 Inhibitor 99.81% Unkown
HY-13237 GSK2578215A Inhibitor 99.82% Unkown
HY-18163 GNE-7915 Inhibitor 99.81% Unkown
HY-13687A IKK 16 hydrochloride Inhibitor 99.95% Unkown
HY-13488 HG-10-102-01 Inhibitor 99.55% Unkown
HY-120085 PFE-360 Inhibitor 99.10% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-P5979 LRRKtide Substrate 99.94% Unkown
HY-12282 GNE-9605 Inhibitor 99.51% Unkown
HY-155150 JH-XII-03-02 Degrader 99.33% Unkown
HY-111493 LRRK2 inhibitor 1 Inhibitor 99.80% Unkown
HY-152107 LRRK2-IN-7 Inhibitor 98.03% Unkown
HY-156429 MK-1468 Inhibitor 99.69% Unkown
HY-B0792 CZC-54252 Inhibitor 98.05% Unkown
HY-142647 EB-42486 Inhibitor 99.62% Unkown
HY-163064 CC-3240 Degrader 98.23% Unkown
HY-16936 JH-II-127 Inhibitor 98.0% Unkown
HY-18163A GNE-7915 tosylate Inhibitor 99.06% Unkown
HY-112855 PF-06454589 Inhibitor 99.91% Unkown
HY-174420 RN277 Inhibitor / Unkown
HY-W107722 IN04 98.51% Unkown
HY-148353 PF-06455943 Inhibitor 98.21% Unkown
HY-152107A (R,R)-LRRK2-IN-7 Inhibitor / Unkown
HY-75368 SRI-31255 Inhibitor 99.88% Unkown
HY-174427 RN341 Inhibitor / Unkown
HY-145317 LRRK2-IN-2 Inhibitor / Unkown
HY-145318 LRRK2-IN-3 Inhibitor / Unkown
HY-162699 LY2023-001 Inhibitor / Unkown
HY-171802 PROTAC LRRK2 Degrader-2 Degrader / Unkown
HY-158365 LRRK2-IN-14 Inhibitor / Unkown
HY-177016 LRRK2-IN-19 Inhibitor / Unkown
HY-168041 LRRK2-IN-15 Inhibitor / Unkown
HY-151444 LRRK2-IN-6 Inhibitor / Unkown
HY-186110 PROTAC LRRK2 Degrader-5 Degrader / Unkown
HY-153058 LRRK2-IN-8 Inhibitor / Unkown
HY-169576 LRRK2-IN-16 Inhibitor / Unkown
HY-182928 LRRK2-IN-21 Inhibitor / Unkown
HY-184198 LRRK2-IN-22 Inhibitor / Unkown
HY-178796 PROTAC LRRK2 Degrader-4 Degrader / Unkown
HY-B0792A CZC-54252 hydrochloride Inhibitor 98.44% Unkown
HY-171801 PROTAC LRRK2 Degrader-1 Degrader / Unkown
HY-151441 LRRK2-IN-5 Inhibitor / Unkown
HY-161571 LRRK2-IN-13 Inhibitor / Unkown
HY-172952 LRRK2-IN-17 Inhibitor / Unkown
HY-178797 PROTAC LRRK2 Degrader-3 Degrader / Unkown
HY-156167 LRRK2-IN-10 Inhibitor / Unkown
HY-180320 Lu AF58786 Inhibitor / Unkown
HY-165543 SRI-29132 Inhibitor / Unkown
HY-134562 PF-06371900 Inhibitor 99.43% Unkown
HY-161570 LRRK2-IN-12 Inhibitor / Unkown
HY-144074 LRRK2-IN-4 Inhibitor / Unkown
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / Unkown
HY-175651 LRRK2-IN-20 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-149187 LRRK2-IN-9 Inhibitor / Unkown
HY-181046 Multi-kinase-IN-14 Inhibitor / Unkown
HY-P10636 Nictide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrk2 NCBI NCBI:120892