MMAF-OtBu
Based on 1 Customer Validation
MMAF-OtBu (Example 2) is a modified MMAF (HY-15579 ). MMAF-OtBu can be used for synthesis of ADCs.
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- Reinheit: 99.83%
- CAS. Nr.: 745017-95-2
- Formel: C43H73N5O8
- Molecular Weight:788.07
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 745017-95-2
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Appearance Solid
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Molecular Weight 788.07
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Formel C43H73N5O8
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Color White to off-white
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SMILES
CC(C)(C)OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](NC)C(C)C)=O)=O)=O)OC)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (63.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2689 mL | 6.3446 mL | 12.6892 mL | 31.7231 mL |
| 5 mM | 0.2538 mL | 1.2689 mL | 2.5378 mL | 6.3446 mL | |
| 10 mM | 0.1269 mL | 0.6345 mL | 1.2689 mL | 3.1723 mL | |
| 15 mM | 0.0846 mL | 0.4230 mL | 0.8459 mL | 2.1149 mL | |
| 20 mM | 0.0634 mL | 0.3172 mL | 0.6345 mL | 1.5862 mL | |
| 25 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL | |
| 30 mM | 0.0423 mL | 0.2115 mL | 0.4230 mL | 1.0574 mL | |
| 40 mM | 0.0317 mL | 0.1586 mL | 0.3172 mL | 0.7931 mL | |
| 50 mM | 0.0254 mL | 0.1269 mL | 0.2538 mL | 0.6345 mL | |
| 60 mM | 0.0211 mL | 0.1057 mL | 0.2115 mL | 0.5287 mL |
MMAF-OtBu Related Classifications
HY-156225 Related Classifications
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