1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin
  3. DC0-NH2

DC0-NH2 

Cat. No.: HY-129379
Handling Instructions

DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component.

For research use only. We do not sell to patients.

DC0-NH2 Chemical Structure

DC0-NH2 Chemical Structure

CAS No. : 615538-51-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1186 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component[1].

IC50 & Target[1]

Duocarmycins

 

In Vitro

DC0-NH2 (0-3 nM; 72 hours) is highly potent against Ramos, Namalwa, and HL60/s cells with IC50 values in the 1 pM to 10 pM range, and has 100 pM range when tested on COLO 205 cells[1].

Cell Viability Assay[1]

Cell Line: Ramos, Namalwa, HL60/s, and COLO 205 Cancer Cells
Concentration: 0-3 nM
Incubation Time: 72 hours
Result: Inhibited Namalwa and HL60/s cells with IC50s of 7 and 30 pM, respectively.
Molecular Weight

550.01

Formula

C₃₁H₂₄ClN₅O₃

CAS No.

615538-51-7

SMILES

O=C(C(N1)=CC2=C1C=CC(N)=C2)NC3=CC4=C(NC(C(N5C[[email protected]@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DC0-NH2ADC CytotoxinCytotoxinADCCPIantibioticInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
DC0-NH2
Cat. No.:
HY-129379
Quantity:
MCE Japan Authorized Agent: