615538-51-7
Chemical Structure
DC0-NH2
- CAS No.: 615538-51-7
- Formula:C31H24ClN5O3
- Molecular Weight:550.01
IUPAC Name: (S)-5-amino-N-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-1H-indol-5-yl)-1H-indole-2-carboxamide
InChIKey: PANFWPQOVGEWSD-GOSISDBHSA-N
SMILES: O=C(C(N1)=CC2=C1C=CC(N)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
Biological Activity: DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DC0-NH2 | 95.65% | DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component. | ||||||||||||||||||||
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Keywords
