PSB-SB-1203
PSB-SB-1203 (Compound 25b) is a dual CB1/CB2 ligand that blocks CB1 but activates CB2 receptors (CB1 Ki 0.244 μM; CB2 Ki 0.210 μM, EC50 0.054 μM). PSB-SB-1203 is promising for research of obesity and cancers.
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- CAS. Nr.: 1399049-80-9
- Formel: C25H30O4
- Molecular Weight:394.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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CB1 0.244 μM (Ki) |
CB2 0.21 μM (Ki) |
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Cell Line
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Type | Value | Description | References |
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| CHO | EC50 |
0.054 μM
Compound: 25b, PSB-SB-1203
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Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation using [3H]-cAMP after 5 mins by liquid scintillation counter
Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation using [3H]-cAMP after 5 mins by liquid scintillation counter
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[PMID: 22916707] |
| CHO | IC50 |
0.261 μM
Compound: 67, PSB-SB- 1203
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Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay
Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay
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[PMID: 23679955] |
| CHO | IC50 |
15.9 μM
Compound: 67, PSB-SB- 1203
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Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay
Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay
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[PMID: 23679955] |
Chemical Information
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CAS. Nr. 1399049-80-9
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Molecular Weight 394.50
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Formel C25H30O4
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SMILES
O=C1OC2=C(C=C1CC3=C(O)C=CC=C3)C(O)=CC(C(C)(CCCCCC)C)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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