Shizukaol B
Based on 1 Customer Validation
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression.
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- Reinheit: 96%
- CAS. Nr.: 142279-40-1
- Formel: C40H44O13
- Molecular Weight:732.77
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
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COX-2 |
iNOS |
IL-1β |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C8166 | CC50 |
0.02 μM
Compound: 8
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Cytotoxicity against human C8166 cells by MTT assay
Cytotoxicity against human C8166 cells by MTT assay
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[PMID: 21650224] |
| RAW264.7 | IC50 |
>50 μM
Compound: 4
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess reagent based colorimetric method
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess reagent based colorimetric method
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[PMID: 30724564] |
| RAW264.7 | IC50 |
0.15 μM
Compound: shizukaol B
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method
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[PMID: 22372956] |
| RAW264.7 | IC50 |
14.79 μM
Compound: 11
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Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
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[PMID: 27177824] |
| WI-38 | IC50 |
16.7 μM
Compound: 30
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Cytotoxicity against human WI38 cells after 72 hrs by CCK8 assay
Cytotoxicity against human WI38 cells after 72 hrs by CCK8 assay
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[PMID: 27997206] |
Shizukaol B (25 μM; 0-60 min) inhibits LPS-mediated (1 μg/mL; 0-60 min) c-Jun N-terminal kinase 1/2 (JNK) activation, without affecting ERK1/2 or p38 phosphorylation[1].
Shizukaol B (12.5-50 μM; 4 h) inhibits LPS-induced (1 μg/mL; 24 h) NO production and expression of iNOS and COX-2 in BV2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 142279-40-1
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Appearance Solid
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Molecular Weight 732.77
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Formel C40H44O13
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Color Off-white to light yellow
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SMILES
COC(/C(C)=C1[C@]2([H])[C@@]34[C@](CC5=C2[C@]([C@@]6([H])[C@]5([H])C6)([C@H](C/1=O)O)C)([H])[C@]7([C@@]8([H])[C@]([C@@]9([C@]7([H])CC3=C(COC(CCC(OC/C=C(C(OC9)=O)/C)=O)=O)C(O4)=O)O)([H])C8)C)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reinheit & Dokumentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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