SHP2-IN-35
SHP2-IN-35 (Compound 3f) is the inhibitor for SHP2. SHP2-IN-35 exhibits antiproliferative activity in cancer cells RKO, SW480 and CT26 with IC50 of 5.72 μM, 3.71 μM and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the cell cycle associated gene expressions, and induces mitochondrial-related autophagy. SHP2-IN-35 inhibits the expression of certain cytokines and chemokines in the tumor microenvironment (TME), thereby regulating the tumor progression.
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- Formel: C34H32FeO6
- Molecular Weight:592.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
Chemical Information
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Molecular Weight 592.46
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Formel C34H32FeO6
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SMILES
O=C(/C=C/C1=CC=C(OC)C(OC)=C1)/C(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)=C/c3cccc3.[][Fe][].c4cccc4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SHP2-IN-35 Related Classifications
HY-170877 Related Classifications
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