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Cat. No.: HY-21302

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SGM8

SGM8 is a selective HCMV UL44 inhibitor, with an IC₅₀ of 4.5 μM for the interaction between HCMV UL44 and full-length HCMV UL54. SGM8 selectively inhibits UL44-dependent long-strand DNA synthesis, while exerting weak inhibitory effects on UL54-only dependent short-strand DNA synthesis. SGM8 can be used in studies related to cytomegalovirus infection.

For research use only. We do not sell to patients.

CAS No.: 882268-09-9
Formula: C₁₂H₁₅NOS₂
Molecular Weight:253.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

SGM8 Chemical Structure

CAS No.: 882268-09-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

SGM8 (0.1-100 μM; 10-60 min) time-dependently inhibits the interaction of HCMV UL44 with the UL54-derived P54 peptide, with an IC₅₀ of 2 μM following 20 min or longer of pre-incubation^[1].
SGM8 (0.1-100 μM) inhibits the interaction of HCMV UL44 with full-length HCMV UL54 with an IC₅₀ of 4.5 μM^[1].
SGM8 (0.1-100 μM) selectively inhibits UL44-dependent long-chain DNA synthesis by HCMV UL54 with an IC₅₀ of 3.2 μM, while showing minimal inhibition of short-chain DNA synthesis by UL54 alone (IC₅₀ > 100 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 882268-09-9
Molecular Weight 253.38
Formula C₁₂H₁₅NOS₂
SMILES

O=C1C2=C(SC=C2CCC1=CN(C)C)SC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen H, et al. A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS infectious diseases. 2017 Feb 10;3(2):112-118.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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SGM8

All DNA/RNA Synthesis Isoforms