Avenanthramide B
Avenanthramide B is an oat phytoalexin, a porcine liver esterase inhibitor, and an amyloglucosidase inhibitor, with an IC50 of 4.4 mg/mL against Aspergillus niger amyloglucosidase. Avenanthramide B increases the activation status of Akt1 and the expression level of eNOS, elevates the levels of NO and cGMP, and reduces the level of superoxide anions. Avenanthramide B acts on amyloglucosidase via a competitive mixed mechanism, functions as a fluorescence quencher, and exerts bidirectional regulatory effects on protein thermal stability. Avenanthramide B serves as a substrate for oat leaf peroxidase. Avenanthramide B can be used in research related to type 2 diabetes.
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- CAS No.: 108605-69-2
- Formule: C17H15NO6
- Masse moléculaire:329.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Akt1 |
Avenanthramide B (1 µM; 24 h) significantly increases intracellular NO levels and cGMP production, reduces superoxide anion generation, enhances Akt1 activation, and upregulates the protein expression level of eNOS in HUVEC cells[2].
Avenanthramide B (50 µM; 10 min) significantly inhibits the activity of porcine liver esterase[1].
Avenanthramide B (31.3-1000 μg/mL) inhibits amyloglucosidase derived from Aspergillus niger via a competitive-dominant mixed-type mechanism, with an IC50 value of 4.4 mg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC
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Concentration:1 µM
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Incubation Time:24 h
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Result:Significantly increased cGMP levels compared to vehicle control.
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Cell Line:HUVEC
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Concentration:1 µM
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Incubation Time:2 h
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Result:Significantly increased the Akt1 phosphorylation/total protein ratio compared to vehicle control, indicating enhanced Akt1 activation.
Significantly increased eNOS protein expression compared to vehicle control.
Chemical Information
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CAS No. 108605-69-2
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Appearance Solid
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Masse moléculaire 329.31
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Formule C17H15NO6
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SMILES
C(O)(=O)C1=C(NC(/C=C/C2=CC(OC)=C(O)C=C2)=O)C=CC(O)=C1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lim H, et al. Compared Inhibitory Activities of Tamoxifen and Avenanthramide B on Liver Esterase and Correlation Based on the Superimposed Structure Between Porcine and Human Liver Esterase. International journal of molecular sciences. 2024 Dec 11;25(24):13291. [Content Brief]
[2]. Serreli G, et al. Ferulic Acid Derivatives and Avenanthramides Modulate Endothelial Function through Maintenance of Nitric Oxide Balance in HUVEC Cells. Nutrients. 2021 Jun 12;13(6):2026. [Content Brief]
[3]. Feng W, et al. Unraveling the inhibition mechanism of avenanthramides on amyloglucosidase: Probing by multi-spectroscopic techniques, enzyme kinetics, and molecular docking simulations. Food chemistry. 2026 Apr 30;509:148552. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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