Dihydroartemisinin-d5
Dihydroartemisinin-d5 (Dihydroqinghaosu-d5) is the d5-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.
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- Formule: C15H19D5O5
- Masse moléculaire:289.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Schistosome |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 71939-50-9
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Masse moléculaire 289.38
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Formule C15H19D5O5
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SMILES
[2H][C@](O1)(O)[C@@](C([2H])([2H])[2H])([2H])C2CC[C@@H](C)C3CC[C@@]4(C)OO[C@]32[C@H]1O4
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Synonyms
Dihydroqinghaosu-d5; β-Dihydroartemisinin-d5; Artenimol-d5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hu W, et al. Dihydroartemisinin induces autophagy by suppressing NF-κB activation. Cancer Lett. 2014;343(2):239-248. [Content Brief]
[2]. Li YJ, et al. Dihydroartemisinin accentuates the anti-tumor effects of photodynamic therapy via inactivation of NF-κB in Eca109 and Ec9706 esophageal cancer cells. Cell Physiol Biochem. 2014;33(5):1527-1536. [Content Brief]
[3]. Li HJ, et al. Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice. Ann Trop Med Parasitol. 2011 Jun;105(4):329-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydroartemisinin-d5 Related Classifications
HY-N0176S3 Related Classifications
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- Dihydroartemisinin-d5
- Dihydroqinghaosu-d5
- β-Dihydroartemisinin-d5
- Artenimol-d5
- Isotope-Labeled Compounds
- Parasite
- NF-κB
- Autophagy
- Reactive Oxygen Species (ROS)
- Drug Metabolite
- RelA/p65
- NB4 cells
- HCT116 cells
- RPMI 8226 cells
- esophageal cancer cells
- autophagy
- IκBα
- Schistosoma japonicum
- HeLa cells
- Inhibitor
- inhibitor
- inhibit