DPYSL2 - dihydropyrimidinase like 2 Gene

Also Known as DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1808

About DPYSL2

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,514,031-26,658,175 (from NCBI)

This gene has 8 transcripts (splice variants), 280 orthologues and 5 paralogues. Broad expression in brain (RPKM 146.0), lung (RPKM 48.2) and 15 other tissues.

Summary

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

DPYSL2 Products (3)

mRNA Protein Name
NM_001197293.3 NP_001184222.1 dihydropyrimidinase-related protein 2 isoform 1
NM_001244604.2 NP_001231533.1 dihydropyrimidinase-related protein 2 isoform 3
NM_001386.6 NP_001377.1 dihydropyrimidinase-related protein 2 isoform 2

DPYSL2 Protein Structure

Amidohydro_1

Amidohydro_1: Amidohydrolase family (64 - 413)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
Protein Preferred Names Protein Names

dihydropyrimidinase-related protein 2

  • collapsin response mediator protein hCRMP-2

DPYSL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
DPYSL2 Q16555 DPYSL3 Homo sapiens Q14195-2
Y2H Prey Pooling
32296183
Intra
DPYSL2 Q16555 DPYSL3 Homo sapiens Q14195-2
Y2H Array
32296183
Intra
DPYSL2 Q16555 DPYSL3 Homo sapiens Q8IXW6
Y2H Prey Pooling
25416956
Intra
DPYSL2 Q16555 DPYSL5 Homo sapiens Q9BPU6
Validated Y2H
25416956
Intra
DPYSL2 Q16555 DPYSL2 Homo sapiens Q16555
Y2H Prey Pooling
32296183
Intra
DPYSL2 Q16555 DPYSL5 Homo sapiens Q9BPU6
Validated Y2H
32296183
Intra
DPYSL2 Q16555 DPYSL5 Homo sapiens Q9BPU6
Y2H Array
25416956
Intra
DPYSL2 Q16555 DPYSL2 Homo sapiens Q16555
Validated Y2H
32296183
Intra
DPYSL2 Q16555 DPYSL2 Homo sapiens Q16555
Y2H Array
25416956
Intra
DPYSL2 Q16555 DPYSL5 Homo sapiens Q9BPU6
Y2H Array
32296183
Intra
DPYSL2 Q16555 DPYSL5 Homo sapiens Q9BPU6
Y2H Prey Pooling
25416956
Intra
DPYSL2 Q16555 DPYSL2 Homo sapiens Q16555
Y2H Array
32296183
Intra
DPYSL2 Q16555 DPYSL2 Homo sapiens Q16555
Y2H Array
29892012
Intra
DPYSL2 Q16555 DPYSL5 Homo sapiens Q9BPU6
Y2H Prey Pooling
32296183
Intra
DPYSL2 Q16555 DPYSL2 Homo sapiens Q16555
Y2H
21516116
Intra
DPYSL2 Q16555 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra
DPYSL2 Q16555 DPYSL2 Homo sapiens Q16555
Y2H Array
31515488
Intra
DPYSL2 Q16555 DPYSL3 Homo sapiens Q14195
Y2H Array
29892012
Intra
DPYSL2 Q16555 CRMP1 Homo sapiens Q14194
Y2H Array
32296183
Intra
DPYSL2 Q16555 CRMP1 Homo sapiens Q14194
Y2H Prey Pooling
32296183
Intra
DPYSL2 Q16555 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
DPYSL2 Q16555 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
DPYSL2 Q16555 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
29892012
Intra
DPYSL2 Q16555 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
31515488
Intra
DPYSL2 Q16555 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra
DPYSL2 Q16555 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPYSL2 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P71816 DPYSL2 Protein, Human (P.pastoris, His) Q16555 (M1-G572) ≥ 90%, as determined by reducing SDS-PAGE.

DPYSL2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P810543 Phospho-CRMP2 (Thr514) Antibody (YA9812) WB Human, Mouse, Rat
HY-P83625 CRMP2 Antibody (YA3370) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03981 DPYSL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18860 Dpysl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25352 Dpysl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DPYSL2 MGD MGI:1349763
Canis familiaris DPYSL2 VGNC VGNC:40083
Bos taurus DPYSL2 VGNC VGNC:28195
Rattus norvegicus DPYSL2 RGD RGD:2517
Macaca mulatta DPYSL2 VGNC VGNC:71984
Felis catus DPYSL2 VGNC VGNC:61615
Others DPYSL2 NCBI