2. Others Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Isotope-Labeled Compounds Endogenous Metabolite iGluR GABA Receptor
  4. Creatinine-d5

Creatinine-d5  (Synonyms: NSC13123-d5)

製品番号: HY-B0504S2 純度: 99.93%
COA 取扱説明書 Technical Support

Creatinine-d5 is the deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.

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Creatinine-d<sub>5</sub>

Creatinine-d5 構造式

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 286 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solution
10 mM * 1 mL in DMSO USD 286 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solid
1 mg $110 在庫あり
5 mg $260 在庫あり
10 mg $416 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Creatinine-d5:

Creatinine-d5 関連抗体

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Human Endogenous Metabolite Microbial Metabolite

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Creatinine-d5 is the deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure[1][2][3][4].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Creatinine-d5 関連抗体
分子量

118.15

分子式

C4H2D5N3O
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])(N1C(NC(C1([2H])[2H])=O)=N)[2H]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 33.33 mg/mL (282.10 mM; Need ultrasonic)

DMSO : 2.5 mg/mL (21.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.4638 mL 42.3191 mL 84.6382 mL
5 mM 1.6928 mL 8.4638 mL 16.9276 mL
10 mM 0.8464 mL 4.2319 mL 8.4638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.93%

COA (254 KB) HNMR (253 KB) LCMS (99 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 8.4638 mL 42.3191 mL 84.6382 mL 211.5954 mL
5 mM 1.6928 mL 8.4638 mL 16.9276 mL 42.3191 mL
10 mM 0.8464 mL 4.2319 mL 8.4638 mL 21.1595 mL
15 mM 0.5643 mL 2.8213 mL 5.6425 mL 14.1064 mL
20 mM 0.4232 mL 2.1160 mL 4.2319 mL 10.5798 mL
H2O 25 mM 0.3386 mL 1.6928 mL 3.3855 mL 8.4638 mL
30 mM 0.2821 mL 1.4106 mL 2.8213 mL 7.0532 mL
40 mM 0.2116 mL 1.0580 mL 2.1160 mL 5.2899 mL
50 mM 0.1693 mL 0.8464 mL 1.6928 mL 4.2319 mL
60 mM 0.1411 mL 0.7053 mL 1.4106 mL 3.5266 mL
80 mM 0.1058 mL 0.5290 mL 1.0580 mL 2.6449 mL
100 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1160 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Creatinine-d5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Creatinine-d5NSC13123-d5Isotope-Labeled CompoundsEndogenous MetaboliteiGluRGABA ReceptorIonotropic glutamate receptorsGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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製品名:
Creatinine-d5
製品番号:
HY-B0504S2
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