Deoxycorticosterone-d₈

Cat. No.: HY-113414S: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Deoxycorticosterone-d₈ is the deuterium labeled Deoxycorticosterone. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor[1][2].

For research use only. We do not sell to patients.

Deoxycorticosterone-d<sub>8</sub> Chemical Structure

Deoxycorticosterone-d₈ Chemical Structure

CAS No. : 55487-63-3

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1 mg	USD 330	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Deoxycorticosterone-d₈:

Deoxycorticosterone In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

338.51

Formula

C₂₁H₂₂D₈O₃

CAS No.

55487-63-3

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C(C3)([2H])[2H])=C(C(=O)C(C4)([2H])[2H])[2H])(CC1)[H])[H])(CC[C@@]2(C(C(O)([2H])[2H])=O)[2H])[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (738.53 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9541 mL	14.7706 mL	29.5412 mL
5 mM	0.5908 mL	2.9541 mL	5.9082 mL
10 mM	0.2954 mL	1.4771 mL	2.9541 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.44%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (255 KB) HNMR (1453 KB) RP-HPLC (1026 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. KAGAWA CM, et al. Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. Science. 1957 Nov 15;126(3281):1015-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9541 mL	14.7706 mL	29.5412 mL	73.8531 mL
	5 mM	0.5908 mL	2.9541 mL	5.9082 mL	14.7706 mL
	10 mM	0.2954 mL	1.4771 mL	2.9541 mL	7.3853 mL
	15 mM	0.1969 mL	0.9847 mL	1.9694 mL	4.9235 mL
	20 mM	0.1477 mL	0.7385 mL	1.4771 mL	3.6927 mL
	25 mM	0.1182 mL	0.5908 mL	1.1816 mL	2.9541 mL
	30 mM	0.0985 mL	0.4924 mL	0.9847 mL	2.4618 mL
	40 mM	0.0739 mL	0.3693 mL	0.7385 mL	1.8463 mL
	50 mM	0.0591 mL	0.2954 mL	0.5908 mL	1.4771 mL
	60 mM	0.0492 mL	0.2462 mL	0.4924 mL	1.2309 mL
	80 mM	0.0369 mL	0.1846 mL	0.3693 mL	0.9232 mL
	100 mM	0.0295 mL	0.1477 mL	0.2954 mL	0.7385 mL