Cystathionine-γ-lyase-IN-1
Based on 1 publication(s) in Google Scholar
Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC50 of 6.3 μM. Cystathionine-γ-lyase-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity : 98.90%
- CAS No.: 2165706-30-7
- Formula: C7H8N2O2S
- Molecular Weight:184.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cystathionine-γ-lyase-IN-1
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Biological Activity
Description
IC50 & Target
IC50: 6.3 μM (CSE)[1]
In Vitro
Cystathionine-γ-lyase-IN-1 (compound 2a) completely abrogates L-cysteine-induced vasorelaxation at a concentration of 100 μM[1].
Cystathionine-γ-lyase-IN-1 (100 μM; 30 minutes) significantly inhibits the increased H2S production stimulated by L-Cys in mouse aorta homogenates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2165706-30-7
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Appearance Solid
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Molecular Weight 184.22
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Formula C7H8N2O2S
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Color White to off-white
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SMILES
O=C([C@H]1NC(SC1)=O)NCC#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Calcium
Drug repurposing DMSO from an old solvent to a new candidate for the treatment of colitis and sepsis in male mice. [Abstract]2026 May 23:136:103155. PMID: 42235215
Solvent & Solubility
In Vitro:
DMSO : 18 mg/mL (97.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 9 mg/mL (48.85 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 5.4283 mL | 27.1415 mL | 54.2829 mL | 135.7073 mL |
| 5 mM | 1.0857 mL | 5.4283 mL | 10.8566 mL | 27.1415 mL | |
| 10 mM | 0.5428 mL | 2.7141 mL | 5.4283 mL | 13.5707 mL | |
| 15 mM | 0.3619 mL | 1.8094 mL | 3.6189 mL | 9.0472 mL | |
| 20 mM | 0.2714 mL | 1.3571 mL | 2.7141 mL | 6.7854 mL | |
| 25 mM | 0.2171 mL | 1.0857 mL | 2.1713 mL | 5.4283 mL | |
| 30 mM | 0.1809 mL | 0.9047 mL | 1.8094 mL | 4.5236 mL | |
| 40 mM | 0.1357 mL | 0.6785 mL | 1.3571 mL | 3.3927 mL | |
| DMSO | 50 mM | 0.1086 mL | 0.5428 mL | 1.0857 mL | 2.7141 mL |
| 60 mM | 0.0905 mL | 0.4524 mL | 0.9047 mL | 2.2618 mL | |
| 80 mM | 0.0679 mL | 0.3393 mL | 0.6785 mL | 1.6963 mL |
Cystathionine-γ-lyase-IN-1 Related Classifications
HY-136211 Related Classifications
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