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Cat. No.: HY-N18266

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10-Hydroxycroomine

10-Hydroxycroomine is a croomine-type alkaloid. 10-Hydroxycroomine can be isolated from the roots of Stemona tuberosa. 10-Hydroxycroomine produces a non-statistically significant reduction in Citric acid (HY-N1428)-induced coughing. 10-Hydroxycroomine can be used for the research of cough.

For research use only. We do not sell to patients.

CAS No.: 1068009-94-8
Formula: C₁₈H₂₇NO₅
Molecular Weight:337.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

10-Hydroxycroomine Chemical Structure

CAS No.: 1068009-94-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

10-Hydroxycroomine (0.25 μmol; icv) produces a non-statistically significant 15-33% reduction in citric acid-induced coughing in Dunkin-Hartley guinea pigs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dunkin-Hartley^[1]
Dosage:

0.25 μmol
Administration:

intracerebroventricular; single dose
Result:

Decreased citric acid-induced coughing by 15-33%, but this inhibition was not statistically significant (P > 0.05).

Chemical Information

CAS No. 1068009-94-8
Molecular Weight 337.41
Formula C₁₈H₂₇NO₅
SMILES

O[C@@H]1[C@]2(OC([C@@H]1C)=O)[C@@]3([H])N(CCCC2)[C@@]([C@]4([H])C[C@@H](C(O4)=O)C)([H])CC3
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin L G, et al. Croomine-and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity[J]. Tetrahedron, 2008, 64(44): 10155-10161.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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