Delequamine  (Synonyms: RS-15385-197)

Delequamine (RS-15385-197) is an orally active and selective α2-adrenergic receptor antagonist with a pK_i of 9.5 for α2-adrenoceptors in rat cortex. Delequamine shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine can be used for the study of erectile dysfunction^[1].

Delequamine (0.4-6.4 mg/kg; oral, single dose) can increase the sexual behavior score in a dose-dependent manner in a model where untrained male rats are exposed to estrogen-progesterone-treated, sexually receptive female rats. Furthermore, the combination of Delequamine (0.4 mg/kg; oral, single dose) and 8-OH-DPAT (HY-112061) (0.1 mg/kg; subcutaneous injection) can increase the percentage of mounts, intromissions, and ejaculations in rats, shorten the ejaculation latency, and reduce the number of intromissions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

350.48

C₁₈H₂₆N₂O₃S

119905-05-4

CS(=O)(N1[C@@]2([H])C[C@@]3([H])C4=CC=C(OC)C=C4CCN3C[C@@]2([H])CCC1)=O

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• [1]. Tallentire D, et al. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996;118(1):63-72.  [Content Brief]