Di-O-methylhonokiol
Based on 1 Customer Validation
Di-O-methylhonokiol is a natural phenolic compound that can be isolated from magnolia flowers. Di-O-methylhonokiol has significant antibacterial activity against Gram-positive bacteria, acid-fast bacilli, and yeast-like and filamentous fungi. Di-O-methylhonokiol can be used in the study of fungal infections.
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- Pureté: 99.59%
- CAS No.: 68592-18-7
- Formule: C20H22O2
- Masse moléculaire:294.39
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CNE2Z | IC50 |
>50 μM
Compound: 1c
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Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 31831382] |
| HepG2 | IC50 |
>135.98 μM
Compound: 9i
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Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
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[PMID: 21853991] |
| HUVEC | IC50 |
>100 μM
Compound: 9i
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Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay
Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay
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[PMID: 21853991] |
| I10 | IC50 |
>50 μM
Compound: 1c
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Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 31831382] |
| Lewis lung carcinoma cell line | IC50 |
>136 μM
Compound: 9i
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Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay
Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay
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[PMID: 21853991] |
| MCF7 | IC50 |
>50 μM
Compound: 1c
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Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 31831382] |
| Oocyte | EC50 |
42.1 μM
Compound: 13
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Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique
Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique
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[PMID: 21699169] |
| RAW264.7 | IC50 |
>100 μM
Compound: 5
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Cytotoxicity against mouse RAW264.7 cells assessed as cell viability by propidium iodide staining based FACS-flow cytometry
Cytotoxicity against mouse RAW264.7 cells assessed as cell viability by propidium iodide staining based FACS-flow cytometry
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[PMID: 22494844] |
| RAW264.7 | IC50 |
40 μM
Compound: 5
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Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
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[PMID: 22494844] |
Chemical Information
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CAS No. 68592-18-7
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Appearance Solid
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Masse moléculaire 294.39
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Formule C20H22O2
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Color White to off-white
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SMILES
COC1=C(CC=C)C=C(C=C1)C2=CC(CC=C)=CC=C2OC
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Pureté et documentation
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Fiche technique (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. A M Clark, et al. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L. J Pharm Sci. 1981 Aug;70(8):951-2. [Content Brief]
[2]. Clark A M, et al. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L[J]. Journal of pharmaceutical sciences, 1981, 70(8): 951-952. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Di-O-methylhonokiol Related Classifications
HY-N12496 Related Classifications
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