2. Disease Areas
  3. Infection Urogenital Disease
  4. Viral Infection Sexually Transmitted Disease
  5. HPV Infection

HPV Infection

Human papillomavirus (HPV) infection is a vaccine-preventable, sexually transmitted infection increasingly recognized as a major cause of oropharyngeal squamous cell carcinoma (OPSCC). HPV-positive OPSCC represents a distinct clinical entity with rising incidence in developed countries, contrasting with declining rates of HPV-negative disease linked to tobacco and alcohol use. Despite shared risk factors and overlapping epidemiology, HPV-positive tumors are associated with significantly better survival outcomes compared to HPV-negative cases. Current treatment involves multimodal therapy including surgery, radiation, and chemotherapy, often leading to substantial morbidity. Ongoing research aims to determine whether treatment de-escalation for HPV-positive OPSCC can preserve high survival rates while reducing long-term complications. Additionally, emerging biomarkers hold promise for improving screening, diagnosis, treatment planning, and surveillance in HPV-related oropharyngeal cancer.

HPV Infection (5):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-116073
    L-Penicillamine 1113-41-3 99.71%
    L-Penicillamine is an orally active serine palmitoyltransferase (SPT) inhibitor. L-Penicillamine inactivates the PLP cofactor by forming adducts, thereby inhibiting SPT activity and reducing sphingolipid biosynthesis. L-Penicillamine not only blocks tumor access to vitamin B6, but also stabilizes the human papillomavirus 16 E6 oncoprotein monomer and inhibits its polymerization, exhibiting a unique anticancer mechanism. L-Penicillamine effectively delays the growth of Sarcoma-180, induces tumor necrosis and prolongs survival (though long-term use may lead to Pyridoxine (HY-B1328) deficiency and weight loss).
    L-Penicillamine
  • HY-P5407
    HD5 798569-33-2
    HD5 is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer.
    HD5
  • HY-P5407A
    HD5 TFA
    HD5 TFA is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 TFA binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 TFA can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer.
    HD5 TFA
  • HY-183322
    Antiviral agent 83
    Antiviral agent 83 is a boronic acid-modified Neocryptolepine (HY-E70250) derivative and is an anti-HPV agent. Antiviral agent 83 bind to the viral capsid protein and/or envelope protein, inducing conformational changes that effectively obstruct the interaction between the virus and host cell receptors. Antiviral agent 83 exhibits inhibitory activity against multiple high-risk HPV strains. Antiviral agent 83 inhibits HPV infection in vitro and in vaginal tract in vivo.
    Antiviral agent 83
  • HY-D3187
    HMRef-αMan 2484831-02-7
    HMRef-αMan is a substrate-based green fluorescent probe (Ex/Em=465 nm/515 nm) targeting MAN2C1 (α-mannosidase). HMRef-αMan can be specifically cleaved by MAN2C1 to generate a highly fluorescent product, which thus gets activated to produce green fluorescence in malignant breast tissues, benign lesions and living cancer cells. The signal intensity of HMRef-αMan is directly correlated with MAN2C1 activity, and it can effectively detect tiny breast cancer lesions with a diameter of less than 1 mm. When used in combination with the red-emitting γ-glutamyl transpeptidase (GGT) probe gGlu-2OMe SiR600 (HY-D3188), HMRef-αMan enables precise optical differentiation of breast tissue types via a dual-color imaging strategy. HMRef-αMan has been widely used in the research of breast diseases such as breast cancer, fibroadenoma, phyllodes tumor and various types of papilloma.
    HMRef-αMan