HDAC6-IN-86
HDAC6-IN-86 is a histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 74 nM, and it exhibits high selectivity for HDAC1. HDAC6-IN-86 induces cell apoptosis, triggers G2/M phase cell cycle arrest, and inhibits the proliferation of glioma cells. HDAC6-IN-86 can be used for the research of glioblastoma multiforme (GBM).
For research use only. We do not sell to patients.
- CAS No.: 2271229-98-0
- Formula: C21H18N2O3S
- Molecular Weight:378.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 74 nM (IC50) |
HDAC6-IN-86 (Compound 6d) potently inhibits the proliferation of U87MG and U118MG glioblastoma cells, with IC50 values of 2.65 μM and 2.79 μM, respectively, while exhibiting low toxicity against normal LO2 hepatocytes (IC50 = 32.64 μM)[1].
HDAC6-IN-86 (1-27 μM; 24 h) induces dose-dependent apoptosis in U87MG glioblastoma cells[1].
HDAC6-IN-86 (1-27 μM; 24 h) induces dose-dependent G2/M cell cycle arrest in U87MG glioblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human glioblastoma U87MG cells
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Concentration:1, 3, 9 and 27 μM
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Incubation Time:24 h
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Result:Induced dose-dependent apoptosis in U87MG cells with total apoptotic rate of 7.78% at 1 μM.
Induced total apoptotic rate of 11.51% at 3 μM.
Induced total apoptotic rate of 17.49% at 9 μM.
Induced total apoptotic rate of 32.02% at 27 μM.
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Cell Line:human glioblastoma U87MG cells
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Concentration:1, 3, 9 and 27 μM
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Incubation Time:24 h
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Result:Induced dose-dependent G2/M phase cell cycle arrest in U87MG cells.
Arrested over 70% of cells in G2/M phase at 27 μM, with a corresponding decrease in the proportion of cells in G0/G1 phase.
Chemical Information
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CAS No. 2271229-98-0
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Molecular Weight 378.44
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Formula C21H18N2O3S
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SMILES
O=C(NO)C(C=C1)=CC=C1CN2C3=CC=CC=C3SC4=C2C=C(OC)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-86 Related Classifications
HY-187210 Related Classifications
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