2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. DM1-PEG4-DBCO

DM1-(PEG)4-DBCO is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DM1-PEG4-DBCO

DM1-PEG4-DBCO 構造式

容量 価格（税別） 在庫状況 数量
1 mg $500 在庫あり
5 mg $1250 在庫あり
10 mg $2000 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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DM1-PEG4-DBCO 関連抗体

Top Publications Citing Use of Products

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

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製品説明

DM1-(PEG)4-DBCO is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

Maytansinoids

 

分子量

1198.79

分子式

C63H80ClN5O16
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=CC(C/C(C)=C/C=C/[C@@H](OC)[C@]2(O)NC(O[C@@]([C@@H](C)[C@@](O3)([H])[C@]3(C)[C@@H](OC([C@H](C)N(C)C(CCCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)=O)=O)CC7=O)([H])C2)=O)=CC(N7C)=C1Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (83.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8342 mL 4.1709 mL 8.3417 mL
5 mM 0.1668 mL 0.8342 mL 1.6683 mL
10 mM 0.0834 mL 0.4171 mL 0.8342 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8342 mL 4.1709 mL 8.3417 mL 20.8544 mL
5 mM 0.1668 mL 0.8342 mL 1.6683 mL 4.1709 mL
10 mM 0.0834 mL 0.4171 mL 0.8342 mL 2.0854 mL
15 mM 0.0556 mL 0.2781 mL 0.5561 mL 1.3903 mL
20 mM 0.0417 mL 0.2085 mL 0.4171 mL 1.0427 mL
25 mM 0.0334 mL 0.1668 mL 0.3337 mL 0.8342 mL
30 mM 0.0278 mL 0.1390 mL 0.2781 mL 0.6951 mL
40 mM 0.0209 mL 0.1043 mL 0.2085 mL 0.5214 mL
50 mM 0.0167 mL 0.0834 mL 0.1668 mL 0.4171 mL
60 mM 0.0139 mL 0.0695 mL 0.1390 mL 0.3476 mL
80 mM 0.0104 mL 0.0521 mL 0.1043 mL 0.2607 mL
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DM1-PEG4-DBCO Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DM1-PEG4-DBCODrug-Linker Conjugates for ADCADCcancerconjugatemaytansinoidInhibitorinhibitorinhibit

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製品名:
DM1-PEG4-DBCO
製品番号:
HY-136261
数量:
MCE 日本正規代理店:

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